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Fig. 1 · Structure
Cat. No.
A14784
CAS No.
58546-56-8
Formula
C30H32O9
Mol. Weight
536.57

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Schisantherin A

Cat. No. A14784 CAS 58546-56-8
Schisantherin A is a dibenzocyclooctadiene that exhibits anti-tussive, sedative, anti-inflammatory, anti-osteoporotic, neuroprotective, cognition enhancing, and cardioprotective activities. In macrophages, Gomisin C decreases LPS-induced expression and activity of iNOS, COX-2, NO, IL-6, and TNF-α.

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Biological Activity

Target & Activity

Target Activity Value
p65  

Cellular Effect

Cell Line Activity Value Description Reference
A549 IC50 > 100 μM Antiproliferative activity against human A549 cells after 72 hrs by SRB assay [PMID: 18063366]
A549 GI50 74.9 μM Growth inhibition of human A549 cells after 48 hrs by SRB assay 10.1039/C6MD00097E
DU-145 GI50 13.3 μM Growth inhibition of human DU145 cells after 48 hrs by SRB assay 10.1039/C6MD00097E
HCT-15 IC50 > 100 μM Antiproliferative activity against human HCT15 cells after 72 hrs by SRB assay [PMID: 18063366]
IMR-32 GI50 3.6 μM Growth inhibition of human IMR32 cells after 48 hrs by SRB assay 10.1039/C6MD00097E
K562 IC50 > 100 μM Antiproliferative activity against human K562 cells after 72 hrs by MTT assay [PMID: 18063366]
MDA-MB-231 GI50 2.8 μM Growth inhibition of human MDA-MB-231 cells after 48 hrs by SRB assay 10.1039/C6MD00097E
MDA-MB-231 IC50 56.4 μM Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by SRB assay [PMID: 18063366]
PANC-1 GI50 > 100 μM Growth inhibition of human PANC1 cells after 48 hrs by SRB assay 10.1039/C6MD00097E
SiHa GI50 14.7 μM Growth inhibition of human SiHa cells after 48 hrs by SRB assay 10.1039/C6MD00097E
SK-HEP1 IC50 70.4 μM Antiproliferative activity against human SK-HEP1 cells after 72 hrs by SRB assay [PMID: 18063366]
SNU-638 IC50 44.7 μM Antiproliferative activity against human SNU638 cells after 72 hrs by SRB assay [PMID: 18063366]
T47D IC50 51.2 μM Antiproliferative activity against human T47D cells after 72 hrs by SRB assay [PMID: 18063366]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 58546-56-8
Formula C30H32O9
Molecular Weight 536.57
Synonyms Gomisin C
SMILES
CC1CC2=CC3=C(C(=C2C4=C(C(=C(C=C4C(C1(C)O)OC(=O)C5=CC=CC=C5)OC)OC)OC)OC)OCO3

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 94 mg/mL (175.18 mM)

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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