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SGC 0946


DOT1L inhibitor

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Catalog No. A12941

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SGC 0946 5mg A12941-5

Regular Price: $60.00

Special Price: $48.00

SGC 0946 10mg A12941-10

Regular Price: $100.00

Special Price: $80.00

SGC 0946 25mg A12941-25

Regular Price: $200.00

Special Price: $160.00

SGC 0946 50mg A12941-50

Regular Price: $350.00

Special Price: $280.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SGC 0946 is a potent DOT1L methyltransferase inhibitor that blocks H3K79 methylation in A431 cells and MCF10A cells.

SGC 0946

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Chemical Information

Catalog Num A12941
Actions Inhibitor
M. Wt 618.57
Formula C28H40BrN7O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
Synonyms SGC0946, SGC-0946
SMILES code CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[[email protected]@H]2[[email protected]]([[email protected]]([[email protected]@H](O2)N3C(=CC4=C3N=CN=C4N)Br)O)O
Chemical Name 1-[3-[[[(2R,3S,4R,5R)-5-(4-Amino-5-bromo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl](isopropyl)amino]propyl]-3-[4-(2,2-dimethylethyl)phenyl]urea

Biological Activity

SGC 0946 is a potent DOT1L methyltransferase inhibitor that blocks H3K79 methylation in A431 cells and MCF10A cells.
DOT1L (Cell-free assay)
0.3 nM

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