Target & Activity
| Target | Activity | Value |
|---|---|---|
| DOT1L (Cell-free assay) | 0.3 nM |
Fig. 1 · Structure
Documents & Downloads
SGC 0946
Cat. No.
A12941
CAS
1561178-17-3
DOT1L inhibitor
SGC 0946 is a potent DOT1L methyltransferase inhibitor that blocks H3K79 methylation in A431 cells and MCF10A cells.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1561178-17-3 |
| Applications | DOT1L inhibitor |
| Formula | C28H40BrN7O4 |
| Molecular Weight | 618.57 |
| SMILES | CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C(=CC4=C3N=CN=C4N)Br)O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 98 mg/mL (158.43 mM) |
| Water | Insoluble |
| Ethanol | 98 mg/mL (158.43 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.