Target & Activity
| Target | Activity | Value |
|---|---|---|
| SIRT1 (Cell-free assay) | EC50 | 0.16 μM |
Fig. 1 · Structure
Documents & Downloads
SRT1720 HCl
Cat. No.
A10862
CAS
1001645-58-4
SIRT1 Activator
SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor, Activator |
| CAS Number | 1001645-58-4 |
| Applications | SIRT1 Activator |
| Formula | C25H23N7OS.HCl |
| Molecular Weight | 506 |
| Synonyms | SRT-1720 |
| SMILES | C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 34 mg/mL (67.19 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Publications
7 publications citing this product
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Eleni Pitsillou, .et al. , Comput Biol Chem, 2020, 89: 107408 PMID: 33137690
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Jie Ren, .et al. , Sleep Breath, 2018, Nov 8 PMID: 30411173
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Rowlands BD, .et al. , J Neurochem, 2017, Mar;140(6):903-918 PMID: 27925207
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Adam Khader, .et al. , J Surg Res, 2017, Nov;219:288-295 PMID: 29078895
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Adam Khader, .et al. , Crit Care Med, 2016, Aug; 44(8): e651-e663 PMID: 26963320
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Benjamin D. Rowlands, .et al. , J Neurosci Res., 2015, Jul;93(7):1147-56 PMID: 25677687
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Khader A, .et al. , Transplantation, 2014, 98(2):148-56 PMID: 24918615