Fig. 1 · Structure

Cat. No.: A10891
CAS No.: 145733-36-4
Formula: C₂₃H₂₁N₇O
Mol. Weight: 411.56

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Tasosartan

Name: Tasosartan
Brand: Adooq Bioscience
SKU: A10891
Availability: InStock

Cat. No. A10891 CAS 145733-36-4

Angiotensin II receptor antagonist

Tasosartan is an angiotensin II receptor antagonist.

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In Vitro Studies

Tasosartan was evaluated in an activity assay using SARS-CoV-2 nsp15, with nsp15 in DMSO as the control. Tasosartan reduced nsp15 activity, and increasing its concentration produced no further change in activity. [1]

Literature-reported observations and conditions; not Adooq-tested protocols or general treatment recommendations.

Tasosartan and nsp15 Activity

Cell-based study · SARS-CoV-2 nsp15 [1]

SARS-CoV-2 nsp15 was preincubated with Tasosartan in DMSO before activity quantification. Tasosartan reduced nsp15 activity, with similar activity observed at the higher concentration.

Measured endpoints — not treatment concentrations
Endpoint	Reported result	Reference
Quantification of nsp15 activity	nsp15 activity nsp15 retained only ~40% of its activity	[1]

Literature-Reported Treatment Conditions

Treatment concentration: 600 and 1000 µM
Exposure duration: 7 min at room temperature
Method: previously incubated
Vehicle: DMSO

Methods and source locations

Compound reported in the paper: Tasosartan

Literature evidence for the named compound in the stated model; no Adooq product-use or lot-performance claim.

2. Materials and Methods > 2.3. RNase Activity Assays (S38, S41, S42); 3. Results > 3.4. Searching for SARS-CoV-2 nsp15 Inhibitors (S171, S174, S177, S178, S181); Figure 7 legend (S233, S234)

Quantification of nsp15 activity: Quantification of nsp15 activity; comparator: nsp15 in the presence of DMSO — 3. Results > 3.4. Searching for SARS-CoV-2 nsp15 Inhibitors (S178, S181); Figure 7 legend (S233)

Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	145733-36-4
Applications	Angiotensin II receptor antagonist
Formula	C₂₃H₂₁N₇O
Molecular Weight	411.56
Synonyms	ANA-756
SMILES	CC1=C2CCC(=O)N(C2=NC(=N1)C)CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Research References

[1] Saramago M, Costa VG, Souza CS, et al. The nsp15 Nuclease as a Good Target to Combat SARS-CoV-2: Mechanism of Action and Its Inactivation with FDA-Approved Drugs. Microorganisms (2022). PMID: 35208797 DOI: 10.3390/microorganisms10020342 Source material