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TCS 21311

Name: TCS 21311
Brand: Adooq Bioscience
SKU: A15365
Availability: InStock

Cat. No. A15365 CAS 1260181-14-3

JAK3 inhibitor

TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). TCS 21311 is selective for JAK3 over JAK1, JAK2 and Tyk 2 (IC50 values are 1017, 2550 and 8055 nM respectively).

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Biological Activity

Target & Activity

Target	Activity	Value
JAK3	IC50	8 nM
JAK2	IC50	2.55 μM
JAK1	IC50	1.017 μM
PKCα	IC50	13 nM
PKCθ	IC50	68 nM
GSK-3β	IC50	3 nM

6 targets · Scroll to view more

Cellular Effect

Cell Line	Activity	Value	Description	Reference
CTLL	IC50	1294 nM	Inhibition of Jak3-mediated IL2-induced Stat5 phosphorylation in mouse CTLL cells by cell-based assay	[PMID: 21155605]
Jurkat	IC50	689 nM	Inhibition of antiTCR/antiCD28-stimulated IL2 production in human Jurkat cells by measuring bioluminescence	[PMID: 21155605]

Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1260181-14-3
Applications	JAK3 inhibitor
Formula	C₂₇H₂₅F₃N₄O₄
Molecular Weight	526.51
SMILES	CC(C)(C(=O)N1CCN(CC1)C2=CC(=C(C=C2)C(F)(F)F)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.