Target & Activity
| Target | Activity | Value |
|---|---|---|
| 5-HT4 Receptor | ||
| 5-HT2B Receptor |
Fig. 1 · Structure
Documents & Downloads
Tegaserod maleate
Cat. No.
A11743
CAS
189188-57-6
5-HT antagonist
Tegaserod functions as a motility stimulant, achieving its desired therapeutic effects through activation of the 5-HT4 receptors of the enteric nervous system in the gastrointestinal tract. It also stimulates gastrointestinal motility and the peristaltic reflex, and allegedly reduces abdominal pain. Additionally, tegaserod is a 5-HT2B receptor antagonist.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 189188-57-6 |
| Applications | 5-HT antagonist |
| Formula | C16H23N5O.C4H4O4 |
| Molecular Weight | 417.46 |
| Synonyms | Zelnorm |
| SMILES | CCCCCN=C(N)NN/C=C/1\C=NC2=C1C=C(C=C2)OC.C(=C\C(=O)O)\C(=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 72 mg/mL (172.47 mM) |
| Water | Insoluble |
| Ethanol | 7 mg/mL (16.77 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.