Target & Activity
| Target | Activity | Value |
|---|---|---|
| p53 | N/A | |
| SIRT2 | 10 μM | |
| SIRT1 | 21 μM | |
| SIRT3 | 67 μM |
Fig. 1 · Structure
Documents & Downloads
Tenovin-6
Cat. No.
A12305
CAS
1011557-82-6
p53 activator
Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1011557-82-6 |
| Applications | p53 activator |
| Formula | C25H34N4O2S |
| Molecular Weight | 454.6 |
| SMILES | CC(C)(C)C1=CC=C(C=C1)C(=O)NC(=S)NC2=CC=C(C=C2)NC(=O)CCCCN(C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 87 mg/mL (191.36 mM) |
| Water | Warmed: 87 mg/mL (191.36 mM) |
| Ethanol | Insoluble |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Publications
1 publication citing this product
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Igase M,, .et al. , Exp Cell Res, 2019, Dec 28:111810 PMID: 31891684