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Fig. 1 · Structure
Cat. No.
A13445
CAS No.
1258494-60-8
Formula
C22H21N3O4
Mol. Weight
391.42

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TH1338

Cat. No. A13445 CAS 1258494-60-8
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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A-375 IC50 7 nM Cytotoxicity against human A375 cells after 72 hrs by alamar blue assay [PMID: 21341674]
Bone marrow cell IC50 110 nM Cytotoxicity against mouse bone marrow cell by CFU-GM assay [PMID: 21341674]
Bone marrow cell IC50 620 nM Cytotoxicity against human bone marrow cell by CFU-GM assay [PMID: 21341674]
DU-145 IC50 1200 nM Cytotoxicity against human DU145 cells after 72 hrs by alamar blue assay [PMID: 21341674]
H69AR IC50 240 nM Cytotoxicity against human H69AR cells overexpressing MDR1 after 72 hrs by alamar blue assay [PMID: 21341674]
HT-29 IC50 300 nM Cytotoxicity against human HT-29 cells after 72 hrs by alamar blue assay [PMID: 21341674]
IGROV-1 IC50 20 nM Cytotoxicity against human IGROV1 cells after 72 hrs by alamar blue assay [PMID: 21341674]
LNCaP IC50 120 nM Cytotoxicity against human LNCAP cells after 72 hrs by alamar blue assay [PMID: 21341674]
Malme-3M IC50 1200 nM Cytotoxicity against human MALME-3M cells after 72 hrs by alamar blue assay [PMID: 21341674]
MES-SA IC50 4 nM Cytotoxicity against human MESSA cells after 72 hrs by alamar blue assay [PMID: 21341674]
MES-SA/Dx5 IC50 12 nM Cytotoxicity against human MES-SA/Dx5 cells overexpressing MDR1 after 72 hrs by alamar blue assay [PMID: 21341674]
NCI-H460 IC50 12 nM Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay [PMID: 21341674]
NCI-H460 IC50 120 nM Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay in presence of 40 mg/ml HSA [PMID: 21341674]
NCI-H460 IC50 7 nM Cytotoxicity against human H460 cells after 72 hrs by alamar blue assay [PMID: 21341674]
NCI-H69 IC50 110 nM Cytotoxicity against human H69 cells after 72 hrs by alamar blue assay [PMID: 21341674]
PC-3 IC50 24 nM Cytotoxicity against human PC3 cells after 72 hrs by alamar blue assay [PMID: 21341674]
SK-MEL-2 IC50 130 nM Cytotoxicity against human SK-MEL-2 cells after 72 hrs by alamar blue assay [PMID: 21341674]

17 records · Scroll to view more

Specifications

Manufacturer Adooq Bioscience
CAS Number 1258494-60-8
Formula C22H21N3O4
Molecular Weight 391.42
SMILES
CCc1c2ccccc2nc-3c1Cn4c3c(c5c(c4=O)COC(=O)[C@@]5(CC)O)N

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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