Fig. 1 · Structure

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Tofogliflozin

Cat. No. A12690 CAS 903565-83-3

SGLT2 inhibitor

Tofogliflozin is an inhibitor of subtype 2 sodium-glucose transport protein (SGLT2), which is responsible for at least 90% of the glucose reabsorption in the kidney.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
CHO IC50 2.9 nM Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 mins [PMID: 22889351]
CHO IC50 8444 nM Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of sodium-dependent [14C]methyl-alpha-D-glucopyranoside uptake after 45 mins [PMID: 22889351]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 903565-83-3
Applications SGLT2 inhibitor
Formula C22H26O6
Molecular Weight 386.44
Synonyms CSG452
SMILES
CCC1=CC=C(C=C1)CC2=CC3=C(CO[C@@]34[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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