TRAM-34

Catalog No.: A12783
Potassium Channel Blocker
TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.
Grouped product items
Product Name Price Stock Qty
TRAM-34 10mg
$45.00
In stock
TRAM-34 25mg
$90.00
In stock
TRAM-34 50mg
$135.00
In stock
TRAM-34 100mg
$225.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's TRAM-34 has been cited by 2 publications
  • Samuel Drinkall, .et al. , Glia, 2022, Jul;70(7):1301-1316 PMID: 35353387
  • Cheong Hoon Seo, .et al. , Transl Res, 2021, Apr 24 PMID: 33905948
  • Biological Activity
    Discription TRAM-34 is a highly selective blocker of intermediate conductance Ca2+-activated K+ channels (KCa3.1) (Kd = 20 nM). Exhibits 200-1500-fold selectivity over KV, BKCa, KCa2, Na+, CRAC and Cl- channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli.
    Targets
    Target Value
    Product Information
    Catalog Num A12783
    Formula C22H17ClN2
    Molecular Weight 344.84
    CAS Number 289905-88-0
    SMILES C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3Cl)N4C=CC=N4
    Synonyms TRAM34, TRAM 34
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 0.36 mg/mL (1.04 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 2% DMSO+corn oil 1 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 29 mL 144.99 mL 289.99 mL
    0.5 mM 5.8 mL 29 mL 58 mL
    1 mM 2.9 mL 14.5 mL 29 mL
    5 mM 0.58 mL 2.9 mL 5.8 mL
    Useful Calculator

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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