TW-37 Bcl-2 inhibitor

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Catalog No. A10955

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
TW-37 10mg A10955-10
$80.00
TW-37 25mg A10955-25
$150.00
TW-37 50mg A10955-50
$250.00
TW-37 100mg A10955-100
$400.00
TW-37 10mM * 1mL in DMSO A10955-10mM-D
$105.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1.

TW-37

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Chemical Information

Catalog Num A10955
Actions Inhibitor
M. Wt 573.7
Formula C33H35NO6S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 877877-35-5
Synonyms TW37
SMILES code CC(C)C1=CC=CC=C1CC2=C(C(=C(C(=C2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C)O)O)O
Chemical Name N-[4-[[2-(1,1-Dimethylethyl)phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2-(1-methylethyl)phenyl]methyl]benzamide

Biological Activity

Description
TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer mediated through a novel pathway involving inactivation of Notch-1 and Jagged-1.
Targets
Mcl-1 (Cell-free assay) Bcl-2 (Cell-free assay) Bcl-xL (Cell-free assay)
0.26 μM(Ki)0.29 μM(Ki)1.11 μM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO 115 mg/mL (200.45 mM)
Water <1 mg/mL (<1 mM)
Ethanol 4 mg/mL (6.97 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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