TWS119

Catalog No.: A11223
GSK-3 Inhibitor
TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM.
Grouped product items
Product Name Price Stock Qty
TWS119 5mg
$50.00
In stock
TWS119 10mg
$75.00
In stock
TWS119 25mg
$160.00
In stock
TWS119 50mg
$250.00
In stock
TWS119 10mM * 1mL in DMSO
$70.00
In stock
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Biological Activity
Discription TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM.
Targets
Target Value
Product Information
Catalog Num A11223
Formula C18H14N4O2
Molecular Weight 318.3
CAS Number 601514-19-6
SMILES C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O
Synonyms TWS-119
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 58 mg/mL (182.19 mM)
Water Insoluble
Ethanol Insoluble
In vivo 1% DMSO+30% polyethylene glycol+1% Tween 80 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 31.42 mL 157.08 mL 314.17 mL
0.5 mM 6.28 mL 31.42 mL 62.83 mL
1 mM 3.14 mL 15.71 mL 31.42 mL
5 mM 0.63 mL 3.14 mL 6.28 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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