TWS119

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GSK-3 Inhibitor

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Catalog No. A11223

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
TWS119 5mg A11223-5

Regular Price: $60.00

Special Price: $51.00

TWS119 10mg A11223-10

Regular Price: $100.00

Special Price: $85.00

TWS119 25mg A11223-25

Regular Price: $200.00

Special Price: $170.00

TWS119 50mg A11223-50

Regular Price: $350.00

Special Price: $297.50

TWS119 10mM * 1mL in DMSO A11223-10mM-D

Regular Price: $97.00

Special Price: $82.45

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM.

TWS119

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Chemical Information

Catalog Num A11223
Actions Inhibitor
M. Wt 318.3
Formula C18H14N4O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 601514-19-6
Synonyms TWS-119
SMILES code C1=CC(=CC(=C1)N)C2=CC3=C(N2)N=CN=C3OC4=CC=CC(=C4)O
Chemical Name 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-phenol

Biological Activity

Description
TWS119 is a 4,6 disubstituted pyrrolopyrimidine that potently inhibits GSK3β with an IC50 value of 30 nM.1 At 400 nM.
Targets
GSK-3β (Cell-free assay)
30 nM

Solubility

Solubility (25°C) * In vitro DMSO 64 mg/mL (201.04 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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