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Fig. 1 · Structure
Cat. No.
A13099
CAS No.
1118460-77-7
Formula
C27H22N2O3
Mol. Weight
422.48

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UCPH 101

Cat. No. A13099 CAS 1118460-77-7

EAAT1 inhibitor

UCPH 101 is a selective non-substrate inhibitor of EAAT1 (IC50 values are 660, >300000 and >300000 nM for EAAT1, EAAT2 and EAAT3 respectively).

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For laboratory research use only. We do not sell to patients.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
HEK293 IC50 0.66 μM Inhibition of human EAAT1 expressed in HEK293 cells assessed as inhibition of 3[H]-D-Aspartate uptake after 6 mins by scintillation counting method [PMID: 22594609]
HEK293 IC50 0.66 μM Inhibition of EAAT1 (unknown origin) stably expressed in HEK293 cells assessed as reduction in [14C]glutamate uptake incubated for 5 mins by microbeta scintillation counting method [PMID: 31774679]
HEK293 IC50 0.66 μM Inhibition of human EAAT1 expressed in HEK293 cells by [3H]D-Asp uptake assay [PMID: 20857912]
HEK293 IC50 120 nM Activity at human EAAT1 expressed in HEK293 cells assessed as inhibition of Glu-induced fluorescent response by FLIPR membrane potential blue assay [PMID: 19161278]
HEK293 IC50 6.3 μM Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells [PMID: 35677430]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1118460-77-7
Applications EAAT1 inhibitor
Formula C27H22N2O3
Molecular Weight 422.48
SMILES
COC1=CC=C(C=C1)C2C(=C(OC3=C2C(=O)CC(C3)C4=CC=CC5=CC=CC=C54)N)C#N

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 76 mg/mL (179.88 mM)
Water Insoluble
Ethanol Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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