Vatalanib (PTK787) 2HCl

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VEGFR inhibitor

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Catalog No. A10967

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Vatalanib 10mg A10967-10

Regular Price: $40.00

Special Price: $34.00

Vatalanib 25mg A10967-25

Regular Price: $80.00

Special Price: $68.00

Vatalanib 50mg A10967-50

Regular Price: $140.00

Special Price: $119.00

Vatalanib 100mg A10967-100

Regular Price: $250.00

Special Price: $212.50

Vatalanib (PTK787) 2HCl 10mM * 1mL in DMSO A10967-10mM-D

Regular Price: $76.00

Special Price: $64.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2.

Vatalanib (PTK787) 2HCl

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Chemical Information

Catalog Num A10967
Actions Inhibitor
M. Wt 419.7
Formula C20H17Cl3N4
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 212141-54-3
Synonyms Vatalanib,PTK787,PTK/ZK
SMILES code C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl
Chemical Name N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride

Biological Activity

Description
Vatalanib (PTK787 or PTK/ZK) is a small molecule protein kinase inhibitor that inhibits angiogenesis that inhibits all known VEGF receptors, as well as platelet-derived growth factor receptor-beta and c-kit, but is most selective for VEGFR-2.
Targets
Target Value
VEGFR2/KDRIC50: 37nM
VEGFR1/FLT1IC50: 77nM
VEGFR2/Flk1IC50: 270nM
PDGFRβIC50: 580nM
VEGFR3/FLT4IC50: 660nM
c-KitIC50: 730nM
c-FmsIC50: 1.4μM

Solubility

Solubility (25°C)* In vitro DMSO 85 mg/mL (202.51 mM)
Water 10 mg/mL (23.82 mM)
Ethanol 6 mg/mL (14.29 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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