Target & Activity
| Target | Activity | Value |
|---|---|---|
| mGluR5 | EC50 | 30 nM |
Fig. 1 · Structure
Documents & Downloads
VU 0357121
Cat. No.
A11754
CAS
433967-28-3
mGluR5 PAM
VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 433967-28-3 |
| Applications | mGluR5 PAM |
| Formula | C17H17F2NO2 |
| Molecular Weight | 305.3 |
| SMILES | CCCCOC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 56 mg/mL (183.41 mM) |
| Water | Insoluble |
| Ethanol | 19 mg/mL (62.23 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.