VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax.
Targets
Target
Value
Product Information
Catalog Num
A11754
Formula
C17H17F2NO2
Molecular Weight
305.3
CAS Number
433967-28-3
SMILES
CCCCOC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)F
Synonyms
VU0357121,VU-0357121
Storage
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Solubility
In vitro
DMSO
56 mg/mL (183.41 mM)
Water
Insoluble
Ethanol
19 mg/mL (62.23 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula: