VU 0357121

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mGluR5 PAM

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Catalog No. A11754

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
VU 0357121 10mg A11754-10
$90.00
VU 0357121 25mg A11754-25
$200.00
VU 0357121 50mg A11754-50
$380.00
VU 0357121 100mg A11754-100
$700.00
VU 0357121 10mM * 1mL in DMSO A11754-10mM-D
$86.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax.

VU 0357121

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Chemical Information

Catalog Num A11754
Actions N/A
M. Wt 305.3
Formula C17H17F2NO2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 433967-28-3
Synonyms VU0357121,VU-0357121
SMILES code CCCCOC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)F
Chemical Name 4-Butoxy-N-(2,4-difluorophenyl)benzamide

Biological Activity

Description
VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax.
Targets
mGluR5
30 nM(EC50)

Solubility

Solubility (25°C)* In vitro DMSO 61 mg/mL (199.79 mM)
Water <1 mg/mL (<1 mM)
Ethanol 21 mg/mL (68.78 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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