VU 0357121

Catalog No.: A11754
mGluR5 PAM
VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax.
Grouped product items
Product Name Price Stock Qty
VU 0357121 10mg
$90.00
In stock
VU 0357121 25mg
$200.00
In stock
VU 0357121 50mg
$380.00
In stock
VU 0357121 100mg
$700.00
In stock
VU 0357121 10mM * 1mL in DMSO
$86.00
In stock
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Biological Activity
Discription VU 0357121 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) with EC50 = 33 nM, 92% Glumax.
Targets
Target Value
Product Information
Catalog Num A11754
Formula C17H17F2NO2
Molecular Weight 305.3
CAS Number 433967-28-3
SMILES CCCCOC1=CC=C(C=C1)C(=O)NC2=C(C=C(C=C2)F)F
Synonyms VU0357121,VU-0357121
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 56 mg/mL (183.41 mM)
Water Insoluble
Ethanol 19 mg/mL (62.23 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.75 mL 163.77 mL 327.55 mL
0.5 mM 6.55 mL 32.75 mL 65.51 mL
1 mM 3.28 mL 16.38 mL 32.75 mL
5 mM 0.66 mL 3.28 mL 6.55 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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