Target & Activity
| Target | Activity | Value |
|---|---|---|
| HCV NS5B 1a | 0.94 μM | |
| HCV NS5B 1b | 1.2 μM |
Fig. 1 · Structure
Documents & Downloads
Cis-Lomibuvir (cis-VX-222)
Cat. No.
A10980
CAS
1026785-59-0
HCV Protease inhibitor
VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.
In Stock
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1026785-59-0 |
| Applications | HCV Protease inhibitor |
| Formula | C25H35NO4S |
| Molecular Weight | 445.6 |
| Synonyms | VCH222; VX222; cis-VX-222 |
| SMILES | CC(C)(C)C#Cc1cc(N(C(=O)[C@H]2CC[C@H](C)CC2)[C@H]2CC[C@@H](O)CC2)c(C(=O)O)s1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 76 mg/mL (170.55 mM) |
| Water | Insoluble |
| Ethanol | 76 mg/mL (170.55 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
In Vivo Preparation
- Concentration
- 28 mg/mL
- Vehicle
- 30% PEG400+0.5% Tween80+5% propylene glycol
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Publications
2 publications citing this product
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Wataru Ito, .et al. , Antivir Chem Chemother, 2015, Dec; 24(5-6): 148-154 PMID: 27503576
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Hui Shen, .et al. , PLoS One., 2013, 8(12): e82299 PMID: 24358168