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HCV Protease inhibitor

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Catalog No. A10980

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
VX-222 5mg A10980-5
VX-222 10mg A10980-10
VX-222 50mg A10980-50
VX-222 100mg A10980-100
VX-222 10mM * 1mL in DMSO A10980-10mM-D

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.


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Chemical Information

Catalog Num A10980
Actions Inhibitor
M. Wt 445.6
Formula C25H35NO4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1026785-59-0
Synonyms VCH222, VX222
Chemical Name 5-(3,3-Dimethyl-1-butyn-1-yl)-3-[(cis-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]-2-thiophenecarboxylic acid

Biological Activity

VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.
0.94 μM1.2 μM


Solubility (25°C) * In vitro DMSO 89 mg/mL (199.72 mM)
Water <1 mg/mL (<1 mM)
Ethanol 89 mg/mL (199.72 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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