Target & Activity
| Target | Activity | Value |
|---|---|---|
| Lck (Cell-free assay) | 2 nM | |
| Src (Cell-free assay) | 6 nM |
Fig. 1 · Structure
Documents & Downloads
WH 4-023
Cat. No.
A14117
CAS
837422-57-8
dual Lck/Src inhibitor
WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 837422-57-8 |
| Applications | dual Lck/Src inhibitor |
| Formula | C32H36N6O4 |
| Molecular Weight | 568.67 |
| Synonyms | WH-4-023,WH4-023 |
| SMILES | CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | Warmed: 12 mg/mL (21.1 mM) |
| Water | Insoluble |
| Ethanol | Warmed: 6 mg/mL (10.55 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
In Vivo Preparation
- Concentration
- 1 mg/mL
- Vehicle
- 5% DMSO+30% PEG 300+5% Tween 80+ddH2O
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.