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Fig. 1 · Structure
Cat. No.
A11609
CAS No.
1234480-50-2
Formula
C26H30N6O3
Mol. Weight
474.55

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XMD8-92

Cat. No. A11609 CAS 1234480-50-2

BMK1/ERK5 inhibitor

XMD8-92 is a potent and selective BMK1/ERK5 inhibitor .

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For laboratory research use only. We do not sell to patients.

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Biological Activity

Target & Activity

Target Activity Value
ERK5 Kd 80 nM

Cellular Effect

Cell Line Activity Value Description Reference
HEK-293T IC50 > 10000 nM Inhibition of cell growth in HEK293T cells incubated for 72 hrs by CellTiter-blue reagent based assay [PMID: 34710325]
HeLa IC50 > 50 μM Antiproliferative activity against human HeLa cells assessed as reduction in cell viability measured after 24 hrs [PMID: 32078308]
HeLa IC50 0.24 μM Inhibition of EGF-induced BMK1 autophosphorylation in human HeLa cells by SDS-PAGE analysis [PMID: 21412406]
HeLa IC50 300 nM Inhibition of ERK5 in human HeLa cells incubated for 15 mins prior to ATP addition by KiNativ profiling method [PMID: 31212132]
HL-60 IC50 10.59 μM Antiproliferative activity against human HL60 cells assessed as reduction in cell viability measured after 24 hrs [PMID: 32078308]
MKN-74 IC50 > 50 μM Antiproliferative activity against human MKN74 cells assessed as reduction in cell viability measured after 24 hrs [PMID: 32078308]
MM1.S IC50 2100 nM Inhibition of cell growth in human MM1.S cells incubated for 72 hrs by CellTiter-blue reagent based assay [PMID: 34710325]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1234480-50-2
Applications BMK1/ERK5 inhibitor
Formula C26H30N6O3
Molecular Weight 474.55
SMILES
CCOC1=C(C=CC(=C1)N2CCC(CC2)O)NC3=NC=C4C(=N3)N(C5=CC=CC=C5C(=O)N4C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO Warmed: 70 mg/mL (147.5 mM)
Water Insoluble
Ethanol Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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