Fig. 1 · Structure
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1,2,3,6,7,8-Hexachlorodibenzofuran
Dioxin-like PCDF
1,2,3,6,7,8-Hexachlorodibenzofuran is a dioxin-like polychlorinated dibenzofuran (PCDF) that primarily targets the aryl hydrocarbon receptor (AhR). It is known to induce the expression of genes related to xenobiotic metabolism, such as aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells, exhibiting EC50 values of 1.47 nM and 1.24 nM, respectively. Additionally, this compound can lead to physiological changes, including weight reduction and thymic atrophy, while stimulating the expression of cytochrome P450 isoforms in vivo. Its application is significant in toxicological research, particularly in understanding dioxin-like activity and its biological impacts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 57117-44-9 |
| Applications | Dioxin-like PCDF |
| Formula | C12H2Cl6O |
| Molecular Weight | 374.86 |
| Synonyms | 1,2,3,6,7,8-HxCDF |
| SMILES | ClC1=C(Cl)C(Cl)=C(OC2=CC(Cl)=C(Cl)C(Cl)=C23)C3=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
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| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.