Fig. 1 · Structure

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1,2,3,6-Tetragalloylglucose

UGT1A1 inhibitor

1,2,3,6-Tetragalloylglucose is a potent UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) inhibitor, with a Ki of 1.68 μM.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A549 ED50 > 10 μg/mL Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay [PMID: 1431932]
HCT-8 ED50 > 10 μg/mL Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay [PMID: 1431932]
KB ED50 > 10 μg/mL Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay [PMID: 1431932]
TE-671 ED50 > 10 μg/mL Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay [PMID: 1431932]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 79886-50-3
Applications UGT1A1 inhibitor
Formula C34H28O22
Molecular Weight 788.57
Synonyms TeGG
SMILES
O=C(C1=CC(O)=C(O)C(O)=C1)O[C@@H]2[C@H]([C@@H]([C@@H](COC(C3=CC(O)=C(O)C(O)=C3)=O)O[C@H]2OC(C4=CC(O)=C(O)C(O)=C4)=O)O)OC(C5=CC(O)=C(O)C(O)=C5)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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