Fig. 1 · Structure
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1,2,4-Trihydroxybenzene
ER Stress Inducer
1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) is an endoplasmic reticulum (ER) stress inducer that primarily targets the PKR-like ER kinase PERK, leading to cytotoxic effects. This compound selectively activates eIF2α phosphorylation, engages the PERK-eIF2α signaling pathway, and promotes the formation of stress granules. Additionally, 1,2,4-Trihydroxybenzene augments oxidative stress, induces DNA double-strand breaks, and disrupts organelles such as mitochondria and the ER, ultimately resulting in cell death. Research indicates its potential applications in anti-tumor studies, blood pressure regulation, and muscle spasm relief.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 533-73-3 |
| Applications | ER Stress Inducer |
| Formula | C6H6O3 |
| Molecular Weight | 126.11 |
| Synonyms | Hydroxyhydroquinone |
| SMILES | OC1=CC=C(O)C=C1O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.