Fig. 1 · Structure
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1,6-Di-O-galloyl-β-D-glucose
RT Inhibitor
1,6-Di-O-galloyl-β-D-glucose is a reverse transcriptase (RT) inhibitor derived from the fruit of Phyllanthus emblica. It demonstrates significant inhibitory activity against HIV-1 reverse transcriptase, with an IC50 value of 270 μM. This compound functions via competitive inhibition of the template-primer and non-competitive inhibition of the substrate dTTP. 1,6-Di-O-galloyl-β-D-glucose is a valuable tool for research in anti-HIV therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 23363-08-8 |
| Applications | RT Inhibitor |
| Formula | C20H20O14 |
| Molecular Weight | 484.36 |
| SMILES | O=C(C1=CC(O)=C(C(O)=C1)O)O[C@@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)COC(C3=CC(O)=C(C(O)=C3)O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.