Fig. 1 · Structure
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1-Ethynylpyrene
Cytochrome P450 Inhibitor
1-Ethynylpyrene is a potent inhibitor of cytochrome P450 enzymes, specifically P450 1A1, 1A2, and 2B1, displaying IC50 values of 0.18, 0.32, and 0.04 μM, respectively. This compound also serves as a versatile click chemistry reagent, featuring an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) for bioconjugation applications. Its unique properties make it valuable for studies involving drug metabolism and chemical biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 34993-56-1 |
| Applications | Cytochrome P450 Inhibitor |
| Formula | C18H10 |
| Molecular Weight | 226.27 |
| SMILES | C#CC1=C(C2=C34)C=CC4=CC=CC3=CC=C2C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.