Fig. 1 · Structure
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1-Hydroxy-ibuprofen
Metabolite of Ibuprofen
1-Hydroxy-ibuprofen is a primary metabolite of ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). This compound exhibits significant anti-inflammatory activity, with reported IC50 values of 13 μM for COX-1 and 370 μM for COX-2. 1-Hydroxy-ibuprofen is utilized in biochemical research to study the pharmacokinetics and metabolic pathways of ibuprofen as well as to investigate its therapeutic effects in inflammation-related studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 53949-53-4 |
| Applications | Metabolite of Ibuprofen |
| Formula | C13H18O3 |
| Molecular Weight | 222.28 |
| SMILES | O=C(O)C(C)C1=CC=C(C(O)C(C)C)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.