Fig. 1 · Structure
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10-Methyl-10-deazaaminopterin
Antifolate
10-Methyl-10-deazaaminopterin is a folate analog that functions as an antifolate, targeting the folate metabolic pathway. It exhibits significant anticancer activity by inhibiting dihydrofolate reductase, thereby interfering with nucleotide synthesis necessary for DNA replication. This compound is utilized in cancer research to explore therapeutic strategies and assess the efficacy of antifolate treatments in various tumor types.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 80576-77-8 |
| Applications | Antifolate |
| Formula | C21H23N7O5 |
| Molecular Weight | 453.45 |
| SMILES | O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(C(C)CC2=NC3=C(N)N=C(N)N=C3N=C2)C=C1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.