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10S,13aR-Antofine N-oxide

Cytotoxic Agent

10S,13aR-Antofine N-oxide is a phenanthroindolizidine N-oxide alkaloid known for its cytotoxic properties. It demonstrates substantial cytotoxic effects in both drug-sensitive (KB-3-1, IC50 = 0.11 μM) and multi-drug-resistant (KB-V1, IC50 = 0.16 μM) carcinoma cell lines, while showing limited interaction with the P-glycoprotein efflux pump. This compound is relevant for cancer research, particularly in exploring alternative therapeutic strategies against resistant tumor types.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	314744-17-7
Applications	Cytotoxic Agent
Formula	C₂₃H₂₅NO₄
Molecular Weight	379.45
SMILES	[O-][N@@+]12CC3=C(C=CC(OC)=C4)C4=C(C=C(C(OC)=C5)OC)C5=C3C[C@@]1([H])CCC2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.