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11β-HSD1-IN-11

Catalog No.: A68949
11β-HSD1 Inhibitor
11β-HSD1-IN-11 is a competitive inhibitor of 11β-HSD1, exhibiting IC50 values of 0.34 μM for rat and 0.13 μM for human enzymes. This compound effectively modulates cortisol metabolism, thereby influencing glucocorticoid signaling pathways. It is useful for studying the role of 11β-HSD1 in metabolic disorders and other physiological processes.
11β-HSD1-IN-11 859721-81-6 11β-HSD1 Inhibitor
Grouped product items
Size Price Stock Qty
1mg
$95.00
In stock
5mg
$220.00
In stock
10mg
$330.00
In stock
25mg
$495.00
In stock
50mg
$680.00
In stock
100mg
$905.00
In stock
500mg
$1,770.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description11β-HSD1-IN-11 is a competitive inhibitor of 11β-HSD1, exhibiting IC50 values of 0.34 μM for rat and 0.13 μM for human enzymes. This compound effectively modulates cortisol metabolism, thereby influencing glucocorticoid signaling pathways. It is useful for studying the role of 11β-HSD1 in metabolic disorders and other physiological processes.
Product Information
Catalog NumA68949
FormulaC15H11F3O3S
Molecular Weight328.31
CAS Number859721-81-6
SMILESFC(C1=CC=C(C(CS(=O)(C2=CC=CC=C2)=O)=O)C=C1)(F)F
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Metabolism > 11β-HSD