11β-HSD1-IN-8

Catalog No.: A68941
11β HSD1 Inhibitor
11β-HSD1-IN-8 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β HSD1) with an IC50 value of 2.3 μM against human 11β HSD1. This compound is of significant interest for research into metabolic disorders, particularly diabetes, and its potential impact on cognitive decline. By modulating the enzymatic activity of 11β HSD1, this reagent can facilitate studies aimed at understanding its role in glucocorticoid metabolism and related pathophysiological conditions.
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Size Price Stock Qty
100mg
$40.00
In stock
250mg
$60.00
In stock
500mg
$95.00
In stock
1g
$140.00
In stock
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description11β-HSD1-IN-8 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β HSD1) with an IC50 value of 2.3 μM against human 11β HSD1. This compound is of significant interest for research into metabolic disorders, particularly diabetes, and its potential impact on cognitive decline. By modulating the enzymatic activity of 11β HSD1, this reagent can facilitate studies aimed at understanding its role in glucocorticoid metabolism and related pathophysiological conditions.
Product Information
Catalog NumA68941
FormulaC10H8F3NO3
Molecular Weight247.17
CAS Number386704-15-0
SMILESCOC(=O)CC(=O)C1=CN=C(C=C1)C(F)(F)F
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