Fig. 1 · Structure
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12,14-Dichlorodehydroabietic acid
BK Channel Opener
12,14-Dichlorodehydroabietic acid is a potent opener of large-conductance calcium-activated potassium (BK) channels. This chlorinated resin acid functions as a non-competitive antagonist of GABAA receptors, effectively blocking GABA-dependent chloride entry in mammalian brain tissue. Additionally, 12,14-Dichlorodehydroabietic acid promotes an increase in cytosolic free calcium levels, thereby stimulating neurotransmitter release, making it valuable for research in neurophysiology and cell signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Opener |
| CAS Number | 65281-77-8 |
| Applications | BK Channel Opener |
| Formula | C20H26Cl2O2 |
| Molecular Weight | 369.33 |
| SMILES | O=C([C@]1(C)CCC[C@]2(C)C3=C(CC[C@@]12[H])C(Cl)=C(C(C)C)C(Cl)=C3)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.