Fig. 1 · Structure
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12-Hydroxynevirapine
Nevirapine Metabolite
12-Hydroxynevirapine is an oxidative metabolite of Nevirapine, a non-nucleoside reverse transcriptase inhibitor used in the treatment of HIV-1 infections. This compound is noteworthy for its role in potentially contributing to hepatotoxicity and skin rashes associated with Nevirapine. In biological systems, 12-Hydroxynevirapine may be bioactivated by sulphotransferases (SULTs), leading to the formation of the reactive metabolite 12-Sulphoxy-nevirapine. Its analysis is essential for understanding the pharmacokinetics and safety profile of Nevirapine.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 133627-24-4 |
| Applications | Nevirapine Metabolite |
| Formula | C15H14N4O2 |
| Molecular Weight | 282.30 |
| Synonyms | 12-hydroxy-NVP; 12-OH-NVP |
| SMILES | O=C1NC2=C(CO)C=CN=C2N(C3CC3)C4=NC=CC=C14 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.