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12-O-Tiglyl-phorbol 13-dodecanoate

Anti-hepatic Fibrosis Agent

12-O-Tiglyl-phorbol 13-dodecanoate (TD13) is an anti-hepatic fibrosis agent that functions as a potential inhibitor of hepatic fibrosis. It effectively reduces the expression of fibronectin, type I collagen, and α-smooth muscle actin in hepatic stellate cells, demonstrating its role in mitigating fibrotic pathways. Derived from the Euphorbiaceae plant Euphorbia fischeriana, TD13 shows minimal toxicity in preclinical models and serves as a valuable reagent for research into hepatic fibrosis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	37394-32-4
Applications	Anti-hepatic Fibrosis Agent
Formula	C₃₇H₅₆O₈
Molecular Weight	628.84
SMILES	CCCCCCCCCCCC(O[C@@]12[C@@]([C@@]3([H])[C@]([C@@H]([C@H]2OC(/C(C)=C/C)=O)C)([C@@]4([H])[C@](CC(CO)=C3)(C(C(C)=C4)=O)O)O)([H])C1(C)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.