123B9 is a potent and selective agonist of the EphA2 receptor, exhibiting a Kd value of 4.0 μM. This compound selectively binds to the ligand-binding domain of the EphA2 tyrosine kinase receptor, facilitating downstream signaling pathways. Importantly, 123B9 does not significantly affect the ligand-binding domains of the closely related EphA3 and EphA4 receptors, making it a valuable tool for targeted studies in cancer research and therapeutic applications involving EphA2 signaling.
123B9 is a potent and selective agonist of the EphA2 receptor, exhibiting a Kd value of 4.0 μM. This compound selectively binds to the ligand-binding domain of the EphA2 tyrosine kinase receptor, facilitating downstream signaling pathways. Importantly, 123B9 does not significantly affect the ligand-binding domains of the closely related EphA3 and EphA4 receptors, making it a valuable tool for targeted studies in cancer research and therapeutic applications involving EphA2 signaling.
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