Fig. 1 · Structure
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14-3-3η Protein inhibitor 1
14-3-3η Inhibitor
14-3-3η Protein Inhibitor 1 is a selective inhibitor of the 14-3-3η protein, exhibiting a dissociation constant (KD) of 35 µM. This compound demonstrates potent anti-proliferative effects in various human liver cancer cell lines, promoting apoptosis and inducing G1-S phase cell cycle arrest. Its favorable metabolic stability makes it a valuable tool for research applications focused on cancer biology and cellular signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2770842-10-7 |
| Applications | 14-3-3η Inhibitor |
| Formula | C29H32N2O3 |
| Molecular Weight | 456.58 |
| SMILES | COC1=CC=CC(CNCC2=C(N(C3=C2C=CC(C(C)C)=C3)CC4=CC=C(C=C4)C)C(O)=O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.