(±)15-HEPE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEPE and 15(S)-HEPE, functioning primarily as an ester product. It demonstrates antimicrobial activity against P. acnes and S. aureus, with MIC values of 128 and 512 mg/L, respectively. Additionally, (±)15-HEPE effectively inhibits the aggregation of isolated rat neutrophils induced by the formyl peptide receptor agonist fMLP, with an IC50 of 4.7 µM. Elevated levels of (±)15-HEPE in bronchoalveolar lavage fluid correlate with conditions such as allergic asthma and COVID-19, highlighting its potential relevance in respiratory research.
(±)15-HEPE is a racemic mixture of the monohydroxy fatty acids 15(R)-HEPE and 15(S)-HEPE, functioning primarily as an ester product. It demonstrates antimicrobial activity against P. acnes and S. aureus, with MIC values of 128 and 512 mg/L, respectively. Additionally, (±)15-HEPE effectively inhibits the aggregation of isolated rat neutrophils induced by the formyl peptide receptor agonist fMLP, with an IC50 of 4.7 µM. Elevated levels of (±)15-HEPE in bronchoalveolar lavage fluid correlate with conditions such as allergic asthma and COVID-19, highlighting its potential relevance in respiratory research.
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