Fig. 1 · Structure
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16-Epiestriol
UGT Inhibitor
16-Epiestriol is a natural stereoisomer of estriol that functions as a UDP-glucuronosyltransferase (UGT) inhibitor. It exhibits key biological activity by attenuating phase II inflammatory processes, notably reducing edema associated with prostaglandin and leukocyte infiltration. With Ki values of 98.1 μM against human UGT1A10 and 162 μM against UGT2B7, 16-Epiestriol is a relevant glucuronidation substrate, primarily modified at the 16-OH and 17-OH sites in liver microsomes. This compound is significant in the study of inflammatory diseases, offering potential insights into therapeutic approaches without impacting glycogenic activity or blood glucose levels.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 547-81-9 |
| Applications | UGT Inhibitor |
| Formula | C18H24O3 |
| Molecular Weight | 288.38 |
| Synonyms | 16β,17β-Estriol |
| SMILES | C[C@@]12[C@@H](O)[C@@H](O)C[C@@]1([H])[C@]3([H])CCC4=C(C=CC(O)=C4)[C@@]3([H])CC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.