Fig. 1 · Structure
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(17R,18S)-Epoxyeicosatetraenoic acid
BKα Activator
(17R,18S)-Epoxyeicosatetraenoic acid is a potent BKα activator that functions as a physiological vasodilator. It enhances the outward potassium current through BK channels, independent of BKβ1 subunits and calcium mobilization. This compound is synthesized via the epoxidation of eicosapentaenoic acid by CYP1A1 variants. (17R,18S)-Epoxyeicosatetraenoic acid is particularly relevant for research on arrhythmia and related cardiovascular disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 725246-18-4 |
| Applications | BKα Activator |
| Formula | C20H30O3 |
| Molecular Weight | 318.45 |
| Synonyms | 17(R),18(S)-EETeTr |
| SMILES | OC(CCC/C=C\C/C=C\C/C=C\C/C=C\C[C@@H]1[C@@H](O1)CC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.