Fig. 1 · Structure
Documents & Downloads
18-Hydroxy-11-deoxy corticosterone
Mineralocorticoid
18-Hydroxy-11-deoxy corticosterone (18-OH-DOC) is a mineralocorticoid involved in the regulation of blood pressure and water-salt homeostasis. It functions as an intermediate in progesterone metabolism and is influenced by adrenocorticotropic hormone (ACTH) and angiotensin II. Research indicates that continuous infusion of 18-OH-DOC can elevate systolic blood pressure in rat models, and its plasma concentrations are notably increased in the db/db mouse model of type 2 diabetes. This suggests a possible role in metabolic dysregulation, making 18-OH-DOC relevant for studies in hypertension, diabetes, and related metabolic disorders.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 379-68-0 |
| Applications | Mineralocorticoid |
| Formula | C21H30O4 |
| Molecular Weight | 346.46 |
| Synonyms | 18-OH-DOC; 11-Deoxy-18-hydroxycorticosterone |
| SMILES | OC[C@@]12[C@](CC[C@@H]2C(CO)=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.