Fig. 1 · Structure
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187-1, N-WASP inhibitor
N-WASP Inhibitor
187-1 is a selective allosteric inhibitor of the neural Wiskott-Aldrich syndrome protein (N-WASP). It effectively hinders actin assembly initiated by phosphatidylinositol 4,5-bisphosphate (PIP2), exhibiting an IC50 value of 2 μM. By stabilizing the autoinhibited conformation of N-WASP, 187-1 disrupts the activation of the Arp2/3 complex, making it a valuable tool for studying actin dynamics and cellular processes associated with the immune response and cytoskeletal organization.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 380488-27-7 |
| Applications | N-WASP Inhibitor |
| Formula | C96H122N18O16 |
| Molecular Weight | 1784.11 |
| SMILES | O=C1N2C(C(=O)N[C@H](CC3=CC=CC=C3)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N5[C@@](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](CC6=CC=CC=C6)C(=O)N7C(C(=O)N[C@H](CC8=CC=CC=C8)C(=O)N[C@@H](CC9=CC=CC=C9)C(=O)N%10[C@@](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]1CC%11=CC=CC=C%11)(CCC%10)[H])(CCC7)[H])(CCC5)[H])(CCC2)[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.