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1D09C3

HLA-DR Monoclonal Antibody

1D09C3 is a fully human anti-HLA-DR monoclonal antibody that targets HLA-DR to promote apoptosis in tumor cells. This compound induces reactive oxygen species (ROS) generation, activates JNK pathways, depolarizes mitochondrial membranes, and facilitates AIF release, contributing to its anti-tumor efficacy. 1D09C3 demonstrates significant anti-tumor activity in JVM-2 and GRANTA-519 cell line xenograft models, enhancing both overall and median survival. It serves as a valuable tool for research into cancers such as chronic lymphocytic leukemia (CLL).

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	791073-97-7
Applications	HLA-DR Monoclonal Antibody

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.