Fig. 1 · Structure
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(1R)-IDH889
Isomer
(1R)-IDH889 is a structural isomer of IDH889 that serves as a valuable experimental control in research. It functions as an allosteric and mutant-specific inhibitor of isocitrate dehydrogenase 1 (IDH1), displaying high selectivity for IDH1 R132 mutations. This compound exhibits potent inhibitory activity on R-2-hydroxyglutarate (2-HG) production, with an IC50 of 0.014 µM, thus making it suitable for studies related to gliomas and other IDH1-mutant cancers.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1429179-08-7 |
| Applications | Isomer |
| Formula | C23H25FN6O2 |
| Molecular Weight | 436.48 |
| SMILES | O=C1OC[C@H](C(C)C)N1C2=NC(N[C@@H](C3=NC=C(C4=CC=C(F)C(C)=C4)C=N3)C)=NC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.