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2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe

E3 Ligase Ligand

2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe is an E3 ligase ligand specifically targeting CRBN. This compound features an additional methyl group on the glutarimide moiety of thalidomide, which disrupts its binding affinity to the E3 ligase. It serves as a negative control for the NAMPT degrader SIAIS630121, making it a valuable tool for research involving targeted protein degradation and molecular pathways regulated by E3 ligases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	26581-83-9
Applications	E3 Ligase Ligand
Formula	C₁₄H₁₄N₂O₃
Molecular Weight	258.27
SMILES	O=C1C2=C(CN1C3C(N(C)C(CC3)=O)=O)C=CC=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.