2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe is an E3 ligase ligand specifically targeting CRBN. This compound features an additional methyl group on the glutarimide moiety of thalidomide, which disrupts its binding affinity to the E3 ligase. It serves as a negative control for the NAMPT degrader SIAIS630121, making it a valuable tool for research involving targeted protein degradation and molecular pathways regulated by E3 ligases.
2-(2,6-Dioxopiperidin-3-yl)phthalimidine NMe is an E3 ligase ligand specifically targeting CRBN. This compound features an additional methyl group on the glutarimide moiety of thalidomide, which disrupts its binding affinity to the E3 ligase. It serves as a negative control for the NAMPT degrader SIAIS630121, making it a valuable tool for research involving targeted protein degradation and molecular pathways regulated by E3 ligases.
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