Fig. 1 · Structure
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2-(2,6-Dioxopiperidin-3-yl)phthalimidine
Thalidomide Analogue
2-(2,6-Dioxopiperidin-3-yl)phthalimidine is a Thalidomide analogue that exhibits enhanced stability against hydrolysis and increased biological activity compared to Thalidomide. This compound has been identified to promote the induction of colon adenocarcinomas in rats when combined with 1,2-dimethylhydrazine, making it a valuable tool for research into cancer mechanisms and potential therapeutic strategies. Its role in studying teratogenic effects further underscores its relevance in chemical biology and pharmacology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 26581-81-7 |
| Applications | Thalidomide Analogue |
| Formula | C13H12N2O3 |
| Molecular Weight | 244.25 |
| Synonyms | EM-12 |
| SMILES | O=C(C(N(CC1=C2C=CC=C1)C2=O)CC3)NC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.