Fig. 1 · Structure
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2′,2′-Difluorodeoxyuridine-13C,15N2
Stable Isotope
2′,2′-Difluorodeoxyuridine-13C,15N2 is a stable isotope-labeled compound targeting nucleotide metabolism. As the primary metabolite of Gemcitabine, it exhibits significant radiosensitizing effects in vitro, dependent on concentration and treatment schedule. Additionally, 2′,2′-Difluorodeoxyuridine induces S phase cell cycle arrest and promotes apoptosis in cancer cells, making it valuable for research into cancer therapeutics and cellular response mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1233921-75-9 |
| Applications | Stable Isotope |
| Formula | C813CH10F215N2O5 |
| Molecular Weight | 267.16 |
| Synonyms | dFdU-13C,15N2; 2',2'-Difluoro-2'-deoxyuridine-13C,15N2 |
| SMILES | O=[13C]([15NH]1)[15N]([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)C=CC1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.