Fig. 1 · Structure
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2,3,4,6,7,8-Hexachlorodibenzofuran
Dioxin-like PCDF
2,3,4,6,7,8-Hexachlorodibenzofuran (2,3,4,6,7,8-HxCDF) is a dioxin-like polychlorinated dibenzofuran (PCDF) known for its ability to activate the aryl hydrocarbon receptor (AhR). This compound induces the expression of genes such as aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells with effective concentrations (EC50) of 0.687 nM and 0.575 nM, respectively. Its biological activity makes it a valuable reagent in toxicological studies and investigations of dioxin-like compounds.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 60851-34-5 |
| Applications | Dioxin-like PCDF |
| Formula | C12H2Cl6O |
| Molecular Weight | 374.86 |
| Synonyms | 2,3,4,6,7,8-HxCDF |
| SMILES | ClC1=C(Cl)C(Cl)=C(OC2=C(Cl)C(Cl)=C(Cl)C=C23)C3=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.