Fig. 1 · Structure
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2,3-Dihydro-3α-methoxynimbolide
Apoptosi
2,3-Dihydro-3α-methoxynimbolide is a limonoid compound that targets apoptosis mechanisms. Isolated from Azadirachta indica A. Juss. var. siamensis Valeton, it demonstrates significant cytotoxic effects across various cell lines. This compound activates caspases-3, -8, and -9, while promoting an increased Bax/Bcl-2 ratio. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis through both mitochondrial pathways and death receptor pathways, making it a valuable tool for cancer research and therapeutic studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1607828-35-2 |
| Applications | Apoptosi |
| Formula | C28H34O8 |
| Molecular Weight | 498.56 |
| SMILES | C[C@@]12[C@@](O[C@@]3([H])C2=C([C@@](C4=COC=C4)([H])C3)C)([H])[C@@]5([H])[C@]6([H])[C@@]([C@H]1CC(OC)=O)(C(C[C@H]([C@]6(C(O5)=O)C)OC)=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.