Fig. 1 · Structure
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2,3-Diphospho-D-glyceric acid pentasodium salt
Vascular Calcification Inhibitor
2,3-Diphospho-D-glyceric acid pentasodium salt is a vascular calcification inhibitor that primarily targets hemoglobin by reducing its oxygen affinity. This compound effectively delays the transformation of colloidal calciprotein particles into crystalline forms, thereby inhibiting calcification in vascular smooth muscle cells while preserving osteoid nodule formation in osteoblast-like cells. Additionally, it exhibits low cytotoxicity in various cell lines and shows minimal interference with β-hematin formation. 2,3-Diphospho-D-glyceric acid pentasodium salt is valuable for investigating the pathophysiological mechanisms underlying vascular calcification and malaria-associated processes.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 102783-53-9 |
| Applications | Vascular Calcification Inhibitor |
| Formula | C3H3Na5O10P2 |
| Molecular Weight | 375.95 |
| Synonyms | 2,3-DPG pentasodium salt |
| SMILES | O=P(O[Na])(O[Na])OC[C@H](C(O[Na])=O)OP(O[Na])(O[Na])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.