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2,5-Epidithia-3,6-dioxopiperazine

Derivative Of ETP

2,5-Epidithia-3,6-dioxopiperazine is a derivative of Epidithiodioxopiperazine (ETP) that targets intracellular pathways to enhance the activity of 2-Cys-Prx, particularly Peroxiredoxin II. This compound demonstrates significant biological activity by inhibiting PDGF-induced proliferation and migration in vascular smooth muscle cells, while promoting similar actions in endothelial cells via VEGF induction. Additionally, 2,5-Epidithia-3,6-dioxopiperazine effectively inhibits the proliferation, migration, and lung metastasis of melanoma cells. It has potential applications in research related to vascular diseases, including hypertension, angina pectoris, and myocardial infarction.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	21056-79-1
Applications	Derivative Of ETP
Formula	C₄H₄N₂O₂S₂
Molecular Weight	176.22
SMILES	O=C(NC1SS2)C2NC1=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.