Fig. 1 · Structure
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(2-(β-Piperidinoethyl)-9-hydroxyellipticinium chloride
SETBP1 Inhibitor
(2-(β-Piperidinoethyl)-9-hydroxyellipticinium chloride) is a selective SETBP1 inhibitor that disrupts the interaction between SETBP1 and XPO1. This compound demonstrates significant biological activities, including the inhibition of colony formation, induction of differentiation and cytotoxicity, and downregulation of SETBP1 target gene transcription. In preclinical studies, (2-(β-Piperidinoethyl)-9-hydroxyellipticinium chloride) has shown to improve survival rates and reduce spleen size in leukemic mouse models. Its applications extend to research on myeloid neoplasms and solid tumors.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 109628-38-8 |
| Applications | SETBP1 Inhibitor |
| Formula | C24H28ClN3O |
| Molecular Weight | 409.95 |
| SMILES | CC1=C2C(NC3=C2C=C(O)C=C3)=C(C)C4=CC=[N+](CCN5CCCCC5)C=C41.[Cl-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.