Fig. 1 · Structure
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2-(Cyclohexylmethyl)-plumbagin
Anticancer Agent
2-(Cyclohexylmethyl)-plumbagin is a naphthoquinone derivative that acts as a selective anticancer agent. It demonstrates significant cytotoxic effects on PANC-1 human pancreatic cancer cells under nutrient-deprived conditions, with a PC50 value of 0.11 µM. This compound effectively reduces the phosphorylation of key signaling proteins Akt and mTOR and induces apoptosis at a concentration of 1 µM. Additionally, 2-(Cyclohexylmethyl)-plumbagin has been shown to decrease tumor volume and weight in mouse models of pancreatic cancer, highlighting its potential for therapeutic application in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 3033734-59-4 |
| Applications | Anticancer Agent |
| Formula | C17H18O3 |
| Molecular Weight | 270.32 |
| SMILES | O=C1C=C(CC2CCCCC2)C(C3=C1C(O)=CC=C3)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.