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2-MPMDQ

α1-Adrenoceptor Antagonist

2-MPMDQ is a selective antagonist of the α1-adrenoceptor, exhibiting a binding affinity (Ki) of 0.37 nM, while demonstrating significantly lower affinity for the α2-adrenoceptor (Ki = 1740 nM). This compound serves as a potent anti-hypertensive agent, making it a valuable tool for the investigation of hypertension and related cardiovascular research applications. Its specificity and efficacy position it as a key reagent for studying the modulation of vascular tone and blood pressure regulation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	149847-77-8
Applications	α1-Adrenoceptor Antagonist
Formula	C₂₃H₂₇N₅O₂
Molecular Weight	405.49
SMILES	O=C1N(C)C2=C(C=CC=C2)C3=NC(CN4CCN(C5=CC=CC=C5OC)CC4)CN13

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.